脑部放疗，上午比下午敏感许多！4 L+ m. c( a+ P5 O. U; M4 X5 r9 `
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Cancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.
) N; A' ^2 }- A' z+ u: e; UGamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?
# r7 a, J. }" b8 sRahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.
: K5 k& u+ F+ Z; F8 Z: I( dSourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
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% e @+ m" N3 U: m6 ]/ K) iAbstract
) b" t, F; e. E# @) a2 p; Z! q, d$ PBACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.
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$ C0 g4 M( C& T; P/ I) G N, cMETHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic." B# L, ~' v2 z' P* g3 [
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RESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).
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9 F8 f4 W# U+ o2 ~# G& ^8 BCONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.
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母亲晚期肺癌跨越13年，这是我家长期
讲述者：不怕辣椒不怕癌整理者：雪漓
在我家抗癌跨越10年之际，鹰版就曾邀请我写一篇
求助：肺腺癌晚期，奥希30个月耐药，
父亲65岁：
23年1月份：持续咳嗽，医院CT后，左肺大量胸腔积液，确诊肺腺癌晚期，胸膜
求助：1a1实体型低分化alk突变复发概
背景：35岁男性，无吸烟史，有熬夜习惯，检查前曾参与新房装修。24年7月底体检第一次
求教：腺癌单药治疗第一次进展后治疗
老爸今年59岁。
首先确诊和治疗情况：
2023年7月做CT胸部积液多，于县城医院确诊肺癌
医养结合：打通肿瘤患者居家营养“最
整理者：雨过天晴肿瘤患者的治疗与康复是一个多维度、系统性的工程，而营养治疗正是其
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显身卡
