脑部放疗，上午比下午敏感许多！
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Cancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.
$ V! V q7 l7 i1 u* j. jGamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?
7 N3 L. t/ O; c0 KRahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.
+ {2 T" d2 F; e* A, OSourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
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, E3 r( q- ~: a4 ~2 J/ z. x. ZAbstract( X& i! F) X R) l
BACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.2 M% R5 Q% t2 V4 G) q: y! x, z
# L) V6 [/ [$ y WMETHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.' M2 P" @4 O" g
% S+ h0 a: t% i. d) x* L q2 VRESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).7 z4 W: ]* ^- \5 y
* e1 S. ]: D$ ]5 }4 q. ^! T: aCONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.8 p$ M$ W: l' K' N6 I4 p- o
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肺癌用药6个月肿瘤消失，我们的治疗
讲述者：步履皆朝阳整理者：pear
总以为肺癌遥不可及，直到它毫无征兆地闯入我们的生
脑膜转移诊疗潘振宇教授科普总结
脑膜转移诊疗潘振宇教授科普总结
脑膜转移 中位治疗生存期 3-6月
脑膜转移的临床表现
25次放疗后，她亲手写下6点放疗战胜
作者：深色系
放疗是通过放射线的电离辐射作用杀灭肿瘤细胞的一种局部治疗方法，它几
肺动脉阻塞，胸闷气短，下一步如何处
请教各位有经验的友友们，目前这种情况如何处理？现在气短的厉害，已无法正常行走，走
各位朋友，我爸爸没有靶向药，pdl只
各位朋友，我爸爸没有靶向药，pdl只有百分之5，这个医治率高不高，我爸爸是肺腺癌，寡
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显身卡
