看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
& @: O9 L9 e: V! D% x, j
* h* B! ]7 e& B5 \4 k; O
& ]0 H I" r8 L/ H- wCurrently available feasibility data for possible combination strategies. $ b) D2 [2 j9 ?) I. r* S. F
————————————————————————————————
3 q% @. d) W, |" d* s$ m. eCombination Feasibility according to preliminary data
+ B( o; s$ | ]- x- C——————————————————————————————————
+ N$ Y0 c' y8 N8 P0 I0 {Bevacizumab + sorafenib Yes, reduced dose
/ E- G& d4 R0 I7 ]Bevacizumab + sunitinib† No 8 g. o8 z {/ D: a% N7 J* R
Bevacizumab + temsirolimus Yes * {. I# L+ L2 U: B
Bevacizumab + everolimus Yes - {2 t7 G; p: Z! ?) I# \9 V
Sorafenib + sunitinib ?
1 m. ~) e! B6 Y5 N3 b3 E, g9 MSorafenib + temsirolimus Yes, reduced dose
9 m0 A! a2 u& \1 d& w0 V1 Q1 LSorafenib + everolimus Yes, reduced dose " \6 k! w; B% b) l
Sunitinib + temsirolimus† No
1 G" Q( t, U" v+ m: CSunitinib + everolimus ?
' i/ [0 t, a; T2 [" l7 q# pTemsirolimus + everolimus ?
( ?5 s- [+ X% w& c2 O5 _' f————————————————————+ a7 s+ \$ m0 C( p/ {. x' U% W
†Led to US FDA warning.
: o' B8 _1 v: V4 g1 f/ ^?: As yet unattempted combination.3 L y' l5 ? X# L$ I( F r
|