看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。* ]' y2 K' c9 t9 y2 Z4 t
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Currently available feasibility data for possible combination strategies.
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Combination Feasibility according to preliminary data 4 _& C- X8 e$ y! {: S
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Bevacizumab + sorafenib Yes, reduced dose ' C5 y- M6 a9 Q' R/ X# L* I7 A& F
Bevacizumab + sunitinib† No
$ d3 r2 |, m; c% J0 X# dBevacizumab + temsirolimus Yes
2 d1 X. e' T9 p9 EBevacizumab + everolimus Yes " g* Y0 X0 q( I- G$ q
Sorafenib + sunitinib ? / c) |# u. L# E1 i! U4 `! c
Sorafenib + temsirolimus Yes, reduced dose : q9 i+ ^3 S0 A( O
Sorafenib + everolimus Yes, reduced dose 2 M& @: ~ Y3 c3 E; I
Sunitinib + temsirolimus† No
5 E# @, T c# K; C) a; Z N) a# dSunitinib + everolimus ?
" Z! h5 D: _& E; X+ zTemsirolimus + everolimus ? " R, g7 z9 n) K" a
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* T! ^. ^" ~% p6 N6 D, i5 L8 X†Led to US FDA warning.
' W6 ~) m, U2 v$ ?# Q" s+ ~: ?) l?: As yet unattempted combination.
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