发给老马备查:, ~$ t! V9 d5 _! _" }2 h
滴水察海(69304838) 15:23:23: Q2 N+ @7 l0 w; ]3 |4 Q x
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
, ]) j c5 [" L7 M; c吉非替尼和S-1连用的依据
2 ^7 w# g$ q2 e0 P3 u* b# tGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
- m1 [- E8 E2 Q2 k. ]是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
7 e& U A7 K, S/ ]* e8 ^6 [( l这样是不是推理出,耐药后,可以用S-1和培美了?
5 N, R4 f8 `( F- ?/ ^结论:; c) q; z, W2 N2 B
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |