发给老马备查:" m0 c) b; }' k: s3 o" V, T' n, e" M
滴水察海(69304838) 15:23:23" u/ b2 f2 p: o3 p
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
0 l* X5 B9 r) C& S- N吉非替尼和S-1连用的依据
, t( f! i1 D8 Z9 `* ~Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
1 u# X. M7 y0 ~- g) ^是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达) K4 z1 n# T0 p' k; d$ e9 K" X
这样是不是推理出,耐药后,可以用S-1和培美了?
: X; j, ^8 f; Z% ]2 E) b& g2 a结论:( {& }. _. V' K' l
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |